Metabolic Support
EIRA Tirzepatide
Research grade, HPLC and MS verified
Tirzepatide is a single 39-residue peptide that activates two incretin receptors, GIP and GLP-1. Its phase 3 trials in type 2 diabetes and obesity are among the largest in the field. It is also an approved pharmaceutical, which sets it apart from most compounds in this library.
For research use only. Not for human or veterinary consumption.
A single peptide that activates both the glucose-dependent insulinotropic polypeptide receptor and the GLP-1 receptor, studied in type 2 diabetes and obesity trials.
Molecular profile
- Compound
- Tirzepatide
- Sequence
- 39-amino-acid synthetic peptide, backbone based on the GIP sequence, with a C20 fatty di-acid moiety conjugated via a linker at Lys20
- Formula
- C225H348N48O68
- Class
- Dual GIP and GLP-1 receptor agonist
- Presentation
- 10mg
Tirzepatide is a 39-amino-acid synthetic peptide, molecular formula C225H348N48O68, that activates both the glucose-dependent insulinotropic polypeptide receptor and the GLP-1 receptor. Its structure is built on the GIP sequence with a C20 fatty di-acid moiety that extends its duration of action to once-weekly dosing. A 2018 discovery paper by Coskun and colleagues characterised that dual-receptor activity in vitro and in diet-induced obese mice.
The human trial record is unusually large. In SURPASS-2, a 40-week phase 3 trial in 1,879 adults with type 2 diabetes, the trial compared tirzepatide at three doses against semaglutide and reported greater mean reductions in glycated haemoglobin and body weight across all three. In SURMOUNT-1, a 72-week phase 3 trial in 2,539 adults with obesity, the trial reported mean weight reductions of 15.0%, 19.5%, and 20.9% at the 5, 10, and 15 mg doses.
One point distinguishes tirzepatide from the rest of this library. It is an approved medicine, marketed as Mounjaro for type 2 diabetes and Zepbound for weight management. The compound Peptheos supplies is a research reagent. It is not the branded product and is not a substitute for it. The trial figures above describe what the studies measured in enrolled participants; they are not statements about any individual.
Supplied for laboratory research use only.
Every batch is characterised by HPLC and mass spectrometry before dispatch. A Certificate of Analysis and a traceable lot number are supplied with every order.
Store as supplied and follow the guidance included with your order. For reconstitution volumes, use the Peptheos reconstitution calculator.
Most lyophilised research peptides are kept cold and away from light. Follow the storage guidance supplied with your order.
From the Range
Certificate of Analysis
Certificate of Analysis for this batch is available on request. Per-batch COA documents will be published here.
